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UPB is now overvalued and could go down -49%

Oct 21, 2025, 12:00 PM
0.00%
Based on our analysis, Upstream Bio has received an overvalued rating of 1 out of 5 stars due to several concerning financial metrics that indicate underperformance relative to its sector. One of the most significant issues is Upstream Bio's net profit margin, which stands at -2650.04%, compared to the sector average of -137.57%. A negative net profit margin indicates that the company is operating at a substantial loss, which raises concerns about its ability to generate profits in the future. Additionally, the company's return on equity (ROE) ratio is -13.37%, while the sector average is -76.41%. Although both figures are negative, Upstream's less severe loss suggests it is not utilizing shareholder equity effectively to generate profits, raising red flags for potential investors. Upstream Bio also reports a return on assets (ROA) ratio of -13.04%, in contrast to the sector average of -47.59%. A negative ROA indicates that the company is not efficiently using its assets to generate earnings, further highlighting operational inefficiencies. Lastly, the price-to-book (PB) ratio stands at 1.88, while the sector average is 2.71. A lower PB ratio may suggest that the company is undervalued relative to its book value; however, this does not compensate for the significant losses reflected in other financial metrics. In summary, the combination of extreme losses in profitability and operational efficiency metrics indicates that Upstream Bio is not performing well compared to its peers, justifying its low valuation rating. This is not a comprehensive overview of our valuation, and should not be viewed as financial advice. Always do your own research before considering an investment.
📡️ Health Care
Overvalued

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