Takeda Pharmaceutical Partners with Innovent to Advance Next-Gen Cancer Therapies

### Takeda Pharmaceutical Company Strengthens Position in Cancer Treatment Through Strategic Collaboration

Takeda Pharmaceutical Company embarks on a transformative partnership with Innovent Biologics, aimed at advancing the development of next-generation immuno-oncology therapies and antibody-drug conjugates. This collaboration focuses on Innovent’s promising investigational candidates, including IBI363, a bispecific antibody fusion protein currently in Phase 3 trials, and IBI343, a CLDN18.2 antibody-drug conjugate also entering late-stage clinical testing. Under the agreement, Takeda will lead the co-development and commercialization of IBI363 in the United States while securing exclusive rights to IBI343 and an option for IBI3001, a bispecific ADC in Phase 1. The partnership highlights Takeda's commitment to expanding its oncology portfolio and its strategic intent to enhance patient outcomes globally.

The financial structure of the collaboration is substantial, with Innovent receiving an upfront payment of $1.2 billion, which includes a strategic equity investment of $100 million and potential milestone payments that could reach up to $11.4 billion. This strategic investment underscores Takeda's confidence in Innovent's innovative capabilities and the potential for these therapies to redefine cancer treatment paradigms. Dr. Hui Zhou, Innovent's Chief R&D Officer for Oncology Pipeline, expresses optimism that the collaboration will leverage the strengths of both organizations, ultimately aiming to deliver novel therapies to patients in need.

This partnership is a key step in Innovent's broader strategic roadmap, enhancing its global footprint as it aspires to become a leading biopharmaceutical entity. The collaboration not only accelerates the development of cutting-edge cancer therapies but also positions Takeda at the forefront of innovation within the oncology sector. As the industry continues to evolve, this alliance may pave the way for significant advancements in cancer treatment options, potentially benefiting thousands of patients worldwide.

In a related development, Takeda also partners with TetraScience in launching the Scientific AI Lighthouse (SAIL) program, aiming to revolutionize biopharma research and manufacturing through advanced AI integration. As a founding partner, Takeda gains priority access to TetraScience's powerful AI and data capabilities, which focus on streamlining drug discovery processes. The SAIL program addresses persistent challenges in pharmaceutical R&D, such as fragmented datasets and inefficient workflows, by providing a suite of tools designed for AI applications.

By collaborating with TetraScience, Takeda aims to enhance productivity and lower costs in drug development, ultimately improving the quality of biopharmaceutical candidates. This initiative reflects Takeda's broader commitment to leveraging technological advancements to transform the landscape of drug development and manufacturing, ensuring it remains a leader in the rapidly evolving biopharmaceutical industry.